Calcium Fructoborate
Supports bone & joint health and helps maintain a healthy inflammatory response.
Ingredient Overview
Calcium fructoborate — known by the patented brand FruiteX-B® — is a nature-identical boron–fructose complex found naturally in fruits and vegetables. It is one of the most bioavailable forms of boron, a trace mineral important for bone and joint metabolism.
Mechanism of Action
Calcium fructoborate helps modulate key markers of a healthy inflammatory response (including C-reactive protein) and supports the body's use of calcium, magnesium and vitamin D. This dual action supports both bone mineral health and day-to-day joint comfort.
Key Results
- 29% improvement in WOMAC score and 27% improvement in McGill Pain Index by day 14 vs baseline
- Significant improvements already at day 7 (25% WOMAC, 21% McGill)
- In a second study, glucosamine + chondroitin was efficacious only when combined with calcium fructoborate
Clinical Studies
Short-term efficacy of calcium fructoborate (CFB) on knee discomfort
- Day 7 vs baseline: 25% improvement in WOMAC score, 21% improvement in McGill Pain Index
- Day 14 vs baseline: 29% improvement in WOMAC score, 27% improvement in McGill Pain Index
- Supplementation with 110 mg CFB twice per day was associated with improving knee discomfort during the 2 weeks of intake
Pietrzkowski Z et al. (2014). Clin Interv Aging, 9, 895–899. doi:10.2147/CIA.S64590.
CFB combined with glucosamine and chondroitin vs glucosamine + chondroitin alone
- Day 7 vs baseline: 15% improvement in WOMAC score, 14% improvement in McGill Index
- Day 14 vs baseline: 24% improvement in WOMAC score, 25% improvement in McGill Index
- Short-term treatment with glucosamine and chondroitin was efficacious only if used in combination with CFB
Reyes-Izquierdo T et al. (2014). J Aging Res Clin Practice, 3(4), 223–228.
Scientific References
- Pietrzkowski Z, Phelan MJ, Keller R, Shu C, Argumedo R, Reyes-Izquierdo T (2014). Short-term efficacy of calcium fructoborate on subjects with knee discomfort. Clin Interv Aging, 9, 895–899.
- Reyes-Izquierdo T, Phelan MJ, Keller R, Shu C, Argumedo R, Pietrzkowski ZB (2014). Short-term efficacy of a combination of glucosamine and chondroitin sulfate compared to a combination with calcium fructoborate (CFB). J Aging Res Clin Practice, 3(4), 223–228.